Metronidazole (oral)

Brand Names: Flagyl, Flagyl ER, Flagyl 375, Protostat

What is the most important information I should know about metronidazole?

Take all of the metronidazole that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.

Do not drink alcohol while taking metronidazole. Flushing, nausea, fast heartbeats, and vomiting may occur when alcohol is ingested during metronidazole therapy.

What is metronidazole?

Metronidazole is an antibiotic. It fights bacteria in your body.

Metronidazole is used to treat infections such as gynecologic infections, bone and joint infections, skin and tissue infections, abdominal infections, and respiratory tract infections.

Metronidazole may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking metronidazole?

Before taking this medication, tell your doctor if you have

• epilepsy or another seizure disorder.
• a stomach or intestinal disease, or
• liver disease,

You may not be able to take metronidazole, or you may require a lower dose or special monitoring during your therapy if you have any of these conditions.

Metronidazole is in the FDA pregnancy category B. This means that it is not likely to harm an unborn baby. Do not, however, take metronidazole without first talking to your doctor if you are pregnant.

Metronidazole passes into breast milk and may affect a nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take metronidazole?

Take metronidazole exactly as directed by your doctor. If you do not understand these instructions, nurse, ask your pharmacist, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water.

Take all of the metronidazole that has been prescribed for you even if you begin to feel better. Your symptoms may start to improve before the infection is completely treated.

Store metronidazole at room temperature away from moisture and heat.

Use injectable metronidazole exactly as directed by your doctor. If you do not understand the instructions, nurse, ask your pharmacist, or doctor to explain them to you.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a metronidazole overdose include nausea, numbness and tingling, loss of coordination, dizziness, vomiting, and seizures.

What should I avoid while taking metronidazole?

Do not drink alcohol while taking metronidazole. Flushing, nausea, fast heartbeats, and vomiting may occur when alcohol is ingested during metronidazole therapy.

Be aware of the alcohol content of other products such as cough and cold medicines. Alcohol in these products can also cause a reaction.

What are the possible side effects of metronidazole?

If you experience any of the following serious side effects, stop taking metronidazole and seek emergency medical attention:

• severe diarrhea.
• dizziness or loss of coordination; or
• numbness or tingling;
• seizures;
• an allergic reaction (swelling of your lips, tongue, or face; closing of your throat; shortness of breath; or hives);

Other, less serious side effects may be more likely to occur. Continue to take metronidazole and talk to your doctor if you experience

• swollen or sore tongue.
• headache; or
• constipation or mild diarrhea;
• an unpleasant metallic taste in your mouth;
• nausea, vomiting, or loss of appetite;
• darkening of your urine;

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect metronidazole?

Before taking this medication, tell your doctor if you are taking any of the following medicines:

• lithium (Lithobid, Eskalith, others). Lithium may also cause dangerous side effects when taken with metronidazole.
• phenytoin (Dilantin). Phenytoin may cause dangerous side effects when taken with metronidazole.
• warfarin (Coumadin). Bleeding may occur if metronidazole and warfarin are used together.
• a barbiturate such as amobarbital (Amytal), Solfoton), phenobarbital (Luminal, or secobarbital (Seconal). These medicines may decrease the effects of metronidazole.

Drugs other than those listed here may also interact with metronidazole. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

Your pharmacist has additional information about metronidazole written for health professionals that you may read.

What does my medication look like?

Metronidazole is available with a prescription under the brand names Flagyl and Protostat. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

• Protostat 500 mg--capsule-shaped, white tablets
• Protostat 250 mg--capsule-shaped, white tablets
• Flagyl 500 mg--oblong, blue tablets
• Flagyl 375 mg--light-green/grey capsules
• Flagyl 250 mg--blue tablets

Remember, never share your medicines with others, keep this and all other medicines out of the reach of children, and use this medication only for the indication prescribed.